This study aimed to investigate the relationship between ZNF582 promoter methylation (ZNF582m) level and radiosensitivity of cervical cancer and its biological basis.This was a prospective multicenter clinical study, comprising two independent cohorts of locally advanced cervical cancer patients.Exfoliated cervical cells were collected at 0, 24, 30
The ZZ domain of HERC2 is a receptor of arginylated substrates
Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein.Here, we show that the ZZ domain of HERC2 (HERC2ZZ) recognizes a mimetic of the Nt-R cargo degradation signal.NMR titration experiments and Events mutagenesis results reveal that the Nt-R mimetic peptid
The Intelligent Control System and Experiments for an Unmanned Wave Glider.
The control system designing of Unmanned Wave Glider (UWG) is challenging since the control system is weak maneuvering, large time-lag and large disturbance, which is difficult to establish accurate mathematical model.Meanwhile, to complete marine environment monitoring in long time scale and large spatial scale autonomously, UWG asks high requirem